What exactly are SARMs, or Selective Androgen Receptor Modulators?
The androgen receptor (AR) is a steroid hormone receptor that plays a vital role in tissue physiology. This receptor includes glucocorticoids, mineralocorticoid receptors, ER, PR, and vitamin D3 receptors – all of which are essential points to discuss in this article.
Circulating testosterone and local dihydrotestosterone are AR ligands that bind to AR and activate it. However, the metabolism and reactivity with other receptors limit how effective therapeutic steroidal androgens is.
SARMs were discovered to “select tissue” receptors to promote the beneficial effects of androgens while avoiding undesirable side effects.
Androgen receptors can be found in muscle, bone, the prostate, secondary sexual organs, and seminal vesicles. However, in bodybuilding terms, the muscles are the only part of seeing the effects of size, mass, and strength.
When testosterone stimulates any androgen cell, it activates an enzyme called 5-a-reductase, which converts testosterone into dihydrotestosterone (DHT), a 10x more powerful androgen hormone than testosterone. The AR is activated by binding the DHT ligand to the AR binding point, which causes conformational changes, phosphorylation, and final binding to the androgen-responsive element (ARE). The ARE then regulates the expression of androgen-responsive genes. When testosterone levels are too high, an enzyme called aromatase converts testosterone into oestrogen, which has estrogenic effects in the cell. A small amount of this occurs naturally, as oestrogen and testosterone are required in a man’s body. When there is too much oestrogen, however, female-like symptoms begin to appear.
To avoid imbalances, the body carefully regulates androgen production through feedback mechanisms under normal conditions. Using any anabolic steroid, SARM or oestrogen modulator disrupts this natural mechanism in either a positive or negative way.
The most common androgen modulators used by athletes are “anabolic steroids.” These have been shown to boost muscle mass, growth, and strength.
Why choose Sarms over steroids?
Because testosterone is a naturally occurring hormone in the body, it is not classified as an anabolic steroid. Using anabolics is the side effects (depending on the type used). This is why SARMs were developed: to find the positive effects of anabolic steroids while avoiding the steroid’s adverse effects.
SARMs do not harm the liver and have little effect on blood pressure. Preloading and on-cycle support supplements are no longer required. As a result, a SARM cycle will be less expensive in the long run than a traditional AAS/PH (steroid/prohormone) cycle. The chances of estrogen-related side effects and water retention are also significantly reduced.
SARMs: How Do They Work?
SARMs bind to androgen receptors in the body, causing their effects to be felt in the places we want them to – primarily in muscle but also bone density. When the SARM binds to the androgen receptor, it signals the body to produce more testosterone, contributing to the results we seek in physique and performance sports, such as increased lean mass, strength, and recovery.
Which SARMs do not suppress the immune system?
SARMs should not be suppressive in theory because they do not supplement exogenous testosterone. However, it is not always that simple, and SARMs users have reported problems due to not completing PCT after heavy cycles. We don’t want to say that there are ‘non-suppressive SARMs,’ because this appears to be highly individual. Milder SARMs, such as Andarine or Ostarine, appear less suppressive at low to moderate doses. Over-the-counter supplements are frequently used to recover from a SARMs cycle.
Which SARMs have the least suppressive effect?
To avoid suppression, begin with one of the milder SARMs mentioned previously at the lowest effective dose and run for short cycles. For example, your first cycle should produce results in 4 weeks! Before increasing the amount or adding another SARM, consider enhancing the effects with a non-hormonal supplement that works through a different pathway, such as cardarine or ibutamoren.
Which SARMs are the most suppressive?
The most suppressive SARMs are also the most potent, mainly when used for very long cycles. The most potent SARMs include YK-11, which we would only recommend to very experienced users.
Can you take different SARMs at the same time?
Yes! SARMs stacks are the logical way to advance your usage if you’ve reached a plateau or are looking for something more potent. This also implies that you can reap the benefits of two different SARMs. For example, the highlight could be lean, dry gains, while the highlight could be improved recovery. Stacking SARMs should only be done under the supervision of a physician.
What are the various types of SARMs?
LGD4033 (AKA Ligandrol)
LGD 4033 Advantages: Whereas Ostarine is one of the best SARMs to use during a cutting cycle, LGD has proven to be an effective bulking agent.
LGD 4033 Side Effects: Given the possibility of high oestrogen side effects, while using the LGD 4033 ligandrol it is advised that you purchase an anti-oestrogen supplement such as a PCT.
MK677 (AKA Ibutamoren)
This is a non-peptidic, orally active, and selective growth hormone secretagogue (secretion-boosting) receptor agonist. It mimics the action of ghrelin (the hormone that regulates appetite, energy distribution, and rate of use) in the stomach, increasing growth hormone and IGF-1 levels while not affecting cortisol levels.
Advantages of MK 677
It has been shown in human studies to increase both muscle mass and bone mineral density. In addition, Ibutamoren has been demonstrated in humans to increase IGF-1 levels by 60% in 6 weeks when taken at a dose of 25mg daily. After 12 months, IGF-1 levels had risen by 72 per cent.
Because ibutamoren is non-hormonal, it does not require PCT after the cycle is completed. It is best used over three months, with the dosage increasing each month. The best time to take MK 677 is at night, right before going to bed. Almost immediately, you should notice a deeper sleep. Don’t be concerned if you wake up with numb or tingly hands. This is a common side effect of having too much GH in the system.
MK 677 Adverse Reactions
• Increased appetite
• Reduced insulin sensitivity
• Retention of water
Half-Life of MK 677
MK 677 has a half-life of about 24 hours. This means you can take it once a day if you prefer. For example, those who take it to increase appetite may do so in the morning, but you may want to take it before bed if it makes you tired.
GW501516 (AKA Cardarine)
This is not, in fact, a SARM. It is, in fact, a PPAR Delta Modulator, a selective agonist with a high affinity for the PPAR (peroxisome proliferator-activated receptors – a group of steroid- and thyroid-sensing proteins that control the expression of genes, thereby regulating cellular development and metabolism).
Advantages of GW 501516
Cardarine supplements also help to regulate the different proteins that the body uses for energy. For the user, this means more energy and endurance, as well as possibly more muscle mass. It’s also possible that GW will improve your blood pressure and lipid profile.
Dosages range from 7mg to 21mg, with 14mg being the “sweet spot.” The average GW cycle lasts 4 to 12 weeks. Because GW is non-hormonal, no PCT is required. It does, however, work well in a SARMs stack to boost fat loss and endurance.
Side Effects of GW 501516: Cardarine supplementation has been linked to several health risks in rat studies, prompting the suspension of human trials of the compound.
Half-Life GW501516: GW501516 Cardarine has a half-life of approximately 24 hours.
RAD 140 (AKA Testolone)
Advantages of Rad 140
RAD is strong enough to reduce the effect of testosterone on the prostate and other undesirable areas. It has even been demonstrated to be more anabolic than testosterone. Dosing appears in the 4mg to 12mg range, with an optimal 4 to 6-week cycle. Because of its shorter half-life (16 hours), RAD must be administered at least twice daily.
Side Effects of Rad 140
- Testosterone suppression
- Half-Life of Rad 140
- 15 to 20 hours
- MK 2866 (also known as S22, Ostarine, or Eno)