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Andarine S4 is mostly used in laboratory research and has a high binding affinity for androgen receptors in skeletal muscle and bone tissues. Research indicates that strategically stimulating these receptors may promote lean muscle growth, increase bone density, and improve overall physical performance.
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S-4 Andarine Powder is a Selective Androgen Receptor Modulator. It has gained popularity for its ability to boost muscle size and performance. S-4, a SARM, binds to androgen receptors in muscle and bone tissues. This binding has been shown in research to increase muscle size and strength.
It may also support sports performance while avoiding many of the harmful side effects linked to anabolic steroids and other anabolic agents. In research, this selective action has been linked with strong anabolic activity but lower androgenic activity, suggesting fewer unwanted androgenic effects compared with the natural effects of testosterone.
One of S-4’s main advantages is its ability to stimulate muscle growth due to its strong receptor binding. This effect can result in bigger muscle size, better muscle density, and higher muscle hardness. S-4 has also been linked to more endurance and stamina, making it a compound of interest in athletic performance research.
S-4 Andarine Powder is also known as Acetamidoxolutamide, Androxolutamide, GTx-007, and S-4. It was developed by GTx Inc Argentina. Early preclinical studies and animal studies on male rats showed that S-4 increased levator ani muscle weight and reduced prostate weight in intact rats. These findings suggested a more selective effect on the muscle compared with the prostate gland.
Because of this, it was investigated for potential relevance in prostate cancer, benign prostatic hyperplasia, and benign prostatic hypertrophy. Results were also published in the Journal of Medicinal Chemistry, highlighting the pharmacodynamics of selective androgen receptor modulators. S-4 reached early phase human testing (phase 1), but development was discontinued before progressing to large-scale human clinical trials, and it was eventually halted in the United States.
Muscle Wasting
S-4 Andarine Powder may help prevent muscle wasting due to its selective androgen receptor activity. By targeting receptors in muscle, it stimulates protein synthesis, which is key for growth and repair. Argentina Research has also linked this activity to steady testosterone levels and explored possible uses in hormone replacement therapy.
Its ability to bind selectively to androgen receptors in muscle may help reduce muscle loss. This makes S-4 Andarine Powder a candidate for preserving lean muscle mass and preventing wasting, especially when breakdown is a concern.
Bone Density
Studies highlighted that S-4 Andarine Powder’s ability to target specific androgen receptors linked to bone density regulation may support an increase in total body bone mineral density. By stimulating these receptors, it potentially promotes bone strength and density, offering benefits in combating conditions like osteoporosis and improving overall bone health.
The anabolic effects of this SARM on bones demonstrate its potential to help prevent bone loss and contribute to the maintenance and enhancement of bone mineral density, making it a promising candidate for those seeking to support bone health and reduce the risk of bone-related issues.
Increased Muscle Mass
Research indicates that S-4 Andarine Powder may help increase muscle growth. By binding to androgen receptors in muscle, it stimulates protein synthesis, which is important for repair and development. Certain clinical studies also explored its ability to support lean gains. It has also been studied with growth hormone in anabolic pathways.
Its anabolic effects suggest it may support muscle growth even during caloric deficits. This makes S-4 Andarine Powder valuable in research on muscle size and strength. The ability to stimulate growth while avoiding many harmful effects of traditional steroids underscores its appeal in studies linked to athletes and fitness.
Cut & Bulk
Because of its high oral bioavailability, S-4 Andarine Powder is flexible and can be studied in cutting, recomposition, or bulking. It has also been tested in cycle therapy, with results showing fewer side effects compared with harsher anabolic substances.
Weight Loss
S-4 Andarine Powder has also been investigated for potential roles in weight loss by targeting specific androgen receptors. By binding selectively, it may increase fat breakdown and oxidation. This may help reduce body fat, even in stubborn areas like the abdomen. Its ability to support fat loss, along with muscle preservation and strength, makes it a promising compound for weight management. Small human trials also suggested links to fat reduction, body composition, and athletic performance.
Compared with other SARMs, S-4 Andarine Powder is often described as milder in its action yet still effective in delivering measurable results, particularly in research focused on muscle growth, strength development, and overall improvements in body composition.
One of the most unique observations linked to this compound has been vision impairment, sometimes reported as vision side effects such as difficulty adjusting to changes in light.
Reported concerns include vision disturbances and testosterone suppression, along with potential liver and endocrine risks that have been noted with SARMs in general. At higher exposures, there have also been reports of serious adverse events. Because of these risks, seeking professional medical advice is strongly advised.
Like our S-4 Andarine Powder? Shop more Andarine S-4 Liquid products here from Direct SARMS Argentina
All SARMs, including S-4 Andarine, are strictly intended for research purposes only and not for human use or human consumption.
[1] Gao W, Reiser PJ, Coss CC, Phelps MA, et al. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005 Nov;146(11):4887-97.
[2] Girgis CM, Mokbel N, Digirolamo DJ. Therapies for musculoskeletal disease: can we treat two birds with one stone? Curr Osteoporos Rep. 2014 Jun;12(2):142-53.
[3] Yavuz M, Demircan T. Exploring the potentials of S4, a selective androgen receptor modulator, in glioblastoma multiforme therapy. Toxicol Appl Pharmacol. 2024 Sep;490:117029.
[4] Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009 May;12(3):232-40.
Formula: C19H18F3N3O6
Molar mass: 441.357 g/mol
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Argentina Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
